Effects of Bisphenol A on Inflammatory Biomarkers at Low Doses in Female Wistar Rats

ABSTRACT

Background and Objective: Bisphenol A (BPA) as an endocrine disruptor, is capable of inducing toxic effects on non-reproductive vital organs. The absorption of BPA has caused extensive damage to the liver and kidney. This study investigates the effects of bisphenol A on some inflammatory biomarkers at low exposure doses in female Wistar rats. Materials and Methods: To ten experimental groups each containing 10 female rats was administered 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 and 1 mg of BPA/kg body weight, respectively for 3 months. The eleventh control group was given water. Animal blood was collected at the end of every week of the studies and the serum sample specimens were analyzed by routine diagnostic procedures for the parameters assayed. Results: The result revealed that hydroperoxidase and myeloperoxidase were significantly decreased when compared with the control group. While hydrogen peroxides were significantly higher than the control group. Conclusion: The findings suggest that bisphenol A upsets the balance of the cellular system and causes disturbance in the cellular oxidative system, suggesting that BPA perturbation on cells of the system at these doses and levels of exposure were transient and increases cellular oxidative stress which is a known inducer of various forms of inflammation.